Investigation of Angiotensinogen M235T and T174M Gene Polymorphisms in Coronary Artery Disease
نویسندگان
چکیده
منابع مشابه
Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure.
Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy. In this study, heart failure patients (n=451) were genotyped for the angiotensinogen M235T and T174M polymorphisms to investigate association with survival (recorded over 4 years of follow-up) and prognostic hormone marke...
متن کاملAngiotensinogen gene polymorphisms M235T/T174M: no excess transmission to hypertensive Chinese.
The gene encoding angiotensinogen (AGT) has been widely studied as a candidate gene for hypertension. Most studies to date have relied on case-control analysis to test for an excess of AGT variants among hypertensive cases compared with normotensive controls. However, with this design, nothing guarantees that a positive finding is due to actual allelic association as opposed to an inappropriate...
متن کاملAngiotensinogen gene M235T polymorphism and risk of coronary artery disease: a meta-analysis.
The angiotensinogen (AGT) gene M235T polymorphism has been suggested to be linked with susceptibility to coronary artery disease (CAD). In the present study, a meta-analysis was performed to assess the correlation between the M235T polymorphism and CAD. Nine studies with a total of 2281 subjects were selected for inclusion in the analysis. The references were retrieved via PubMed, China Nationa...
متن کاملAssociation between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis
BACKGROUND Angiotensinogen (AGT) T174M gene polymorphism has been suggested to be linked to risk of coronary artery disease, however, results from studies of this association have been inconsistent. In this study, we assess the relationship between AGT T174M gene polymorphism and coronary artery disease. METHODS We conducted a meta-analysis of 18 case-control studies with 8,147 coronary arter...
متن کاملRelation Between M235T Polymorphism of the Angiotensinogen Gene and Coronary Artery Disease in Taiwanese: An Angiography-Controlled Study
Background: Polymorphisms of the renin-angiotensin-aldosterone system have been found in association with coronary artery disease (CAD). The M235T polymorphism is the most important angiotensinogen (AGT) genetic variant. The relationship between AGT gene polymorphisms and CAD has been investigated in only a few studies, however, with conflicting results. In most of these studies, not all partic...
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ژورنال
عنوان ژورنال: Erciyes medical journal
سال: 2021
ISSN: ['2149-2247']
DOI: https://doi.org/10.14744/etd.2021.08784